Article NDPK synthesizes the formation of GDP from GTP via dephosphorylation. Hum Mol Genet. Interestingly, CL-binding of NDPK-D/NME4 also modulates its NDP kinase activity. Keywords: Cell Death Differ. 2015;46:691700. Escherichia coli (strain K12) Amino acids. The binding may be indirect by using the signaling complex.[20]. https://doi.org/10.1007/s00425-020-03355-9, DOI: https://doi.org/10.1007/s00425-020-03355-9. Bgee. OncomiR-196 promotes an invasive phenotype in oral cancer through the NME4-JNK-TIMP1-MMP signaling pathway. Wona Ding, Botao Zhang or Shihua Zhu. Epub 2013 Oct 28. IV. Epub 2022 Jun 21. Annu Rev Phytopathol 55(1):401425, Blilou I, Xu J, Wildwater M, Willemsen V, Paponov I, Friml J, Heidstra R, Aida M, Palme K, Scheres B (2005) The PIN auxin efflux facilitator network controls growth and patterning in Arabidopsis roots. 2013 Nov 12;110(46):18596-601. doi: 10.1073/pnas.1310849110. Plant Mol Biol 23:10871090, Ye W, Hu S, Wu L, Ge C, Cui Y, Chen P, Wang X, Xu J, Ren D, Dong G, Qian Q, Guo L (2016) White stripe leaf 12 (WSL12), encoding a nucleoside diphosphate kinase 2 (OsNDPK2), regulates chloroplast development and abiotic stress response in rice (Oryzasativa L.). Steeg PS, Bevilacqua G, Kopper L, et al. ATP + nucleoside 5'-phosphate AMP + 5'-phosphonucleoside 3'-diphosphate. These sites define the two molecular functions of NME4: (i) NTP and ADP generation from mitochondrial ATP and NDPs, and (ii) intermembrane transfer of cardiolipin and other anionic phospholipids by simultaneously binding inner and outer mitochondrial membrane. 2012;26:217586. These proteins go about interrupting metastasis by binding metastasis-promoting proteins. The .gov means its official. Muhonen WW, Lambeth DO. The GABA transaminase, ABAT, is essential for mitochondrial nucleoside metabolism. 2007;67:75565. Osndpk4 showed enhanced resistance to the bacterial pathogen Xanthomonas oryzae pv. NDPK activities maintain an equilibrium between the concentrations of different nucleoside triphosphates such as, for example, when guanosine triphosphate (GTP) produced in the citric acid (Krebs) cycle is converted to adenosine triphosphate (ATP). Neural Dev. The systematic name of this enzyme class is ATP:nucleoside-5'-phosphate diphosphotransferase. In our hands, no nuclear NME4 has been observed in various human cell lines, even when overexpressed. [3] Therefore, NDPK is the source of RNA and DNA precursors, except ATP. Biochem J. 2014;344:15105. Further, a deletion in the 16p13.3 chromosome region containing the NME4 gene was observed in testicular germ cell tumors of adolescent and young adult men by comparative genomic hybridization microarray with no mention of the mono-allelic or bi-allelic nature of the deletion [63]. Would you like email updates of new search results? Lacombe, ML., Tokarska-Schlattner, M., Boissan, M. et al. An interesting structural feature of NDPK-D/NME4 is the serine residue at position 129, which is a proline in all other group I NMEs. Ten paralogous genes code for the proteins NDPKs, which are separated into two groups. Wambaugh MA, Shakya VPS, Lewis AJ, Mulvey MA, Brown JCS. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). 2006;400:1638. Hensen F, Cansiz S, Gerhold JM, Spelbrink JN. Nm23-H1 homologs suppress tumor cell motility and anchorage independent growth. The transcriptomic change in roots of Osndpk4 was analyzed by RNA-seq. The other group genes code for other various proteins that display low or no NDPK activities. Federal government websites often end in .gov or .mil. In the intermembrane/cristae space, NDPK was proposed to supply NTP at the expense of ATP, synthesized by oxidative phosphorylation, and of NDP, freely diffusible from cytoplasm through the outer membrane [11]. Hamilton HM, Wilson R, Blythe M, Nehring RB, Fonville NC, Louis EJ, Rosenberg SM. OPA1 disease alleles causing dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation. Nme1 and Nme2 as a suppressor of metastasis, "PDB 1jxv structure summary Protein Data Bank in Europe (PDBe) EMBL-EBI", "Nucleoside diphosphate kinase (IPR001564)", "X-ray structure of nucleoside diphosphate kinase", "NME1 - Nucleoside diphosphate kinase A - Homo sapiens (Human) - NME1 gene & protein", "Increased activity of membrane-associated nucleoside diphosphate kinase and inhibition of cAMP synthesis in failing human myocardium", "AMPK directly inhibits NDPK through a phosphoserine switch to maintain cellular homeostasis", "spoT - Bifunctional (p)ppGpp synthase/hydrolase SpoT - Escherichia coli (strain K12) - spoT gene & protein", "G proteins: more than transducers of receptor-generated signals? Masse K, Dabernat S, Bourbon PM, et al. MyBioSource.com. Pedersen PL. In enzymology, a thiamine-diphosphate kinase is an enzyme involved in thiamine metabolism.It catalyzes the chemical reaction. Moynie L, Giraud MF, Georgescauld F, Lascu I, Dautant A. In oral cancer, miR-196 was highly overexpressed in cancer tissue and correlated with lymph node metastasis. General description. David Molina-Granada, Emiliano Gonzlez-Vioque, Ramon Mart, Nikolaus Pfanner, Bettina Warscheid & Nils Wiedemann, Marta Giacomello, Aswin Pyakurel, Luca Scorrano, Seiko Nakamura, Aiko Matsui, Toshihiko Oka, Wenjun Wang, Jianshuang Li, Qinghua Zhou, Zachary A. Kemmerer, Kyle P. Robinson, David J. Pagliarini, Laboratory Investigation Careers. Other known mitochondrial NDPK proteins that possess a canonical mitochondrial targeting sequence are found in amoeba [8], plants [26], and green alga [27]. Differential expression of nm23 genes in adult mouse dorsal root ganglia. MeSH The potential influence of artefactual interference by tissue phenolics and ascorbate. NDPK's roles in these NTPs differ; generally, kinases bring in NTPs for nucleic acid synthesis. J Pathol. Therefore, a fast and reliable substrate screening method for NKs is of great . Plant Physiol 122(2):447452, Parks RE, Aganwal RP (1973) 9 nucleoside diphosphokinases. In addition, transcriptomic analysis showed that OsNDPK4 was significantly associated with a number of biological processes, including translation, protein modification, metabolism, biotic stress response, etc. Ding W, Wu J, Ye J, Zheng W, Wang S, Zhu X, Zhou J, Pan Z, Zhang B, Zhu S. Ann Bot. FEBS Lett 508(2):272276, Takatsuka H, Umeda M (2014) Hormonal control of cell division and elongation along differentiation trajectories in roots. CAS FEBS Lett. Hou Y, Wang L, Wang L, Liu L, Li L, Sun L, Rao Q, Zhang J, Huang S. BMC Plant Biol. The results confirm that NDPkinase expression increases in malignant cells of breast carcinomas, but cannot be considered as a biological marker of metastatic dissemination. [33] reported that NME4 expression was decreased during differentiation of HL-60 cells to macrophages and neutrophils. C-terminal lysines determine phospholipid interaction of sarcomeric mitochondrial creatine kinase. A nuclear localization of NME4 was recently reported and related to NME4 deacetylation via SIRT1 [32]. Xiong L, Yi F, Yu Q, Huang X, Ao K, Wang Y, Xie Y. BMC Microbiol. 2021 Aug;63(8):719-731. doi: 10.1007/s12033-021-00338-3. These data suggest that a specific mitochondrial membrane association appeared late in evolution and could be important for some mitochondrial functions that evolved with vertebrates, including cristae remodeling [43] or certain features of mitophagy, for which NDPK-D/NME4 provides functional support (see below). Thus, the two substrates of this enzyme are ATP and nucleoside 5'-phosphate, whereas its two products are AMP and 5'-phosphonucleoside 3'-diphosphate.. Learn more about Institutional subscriptions, Ahsan N, Lee DG, Lee KW, Alam I, Lee SH, Bahk JD, Lee BH (2008) Glyphosate-induced oxidative stress in rice leaves revealed by proteomic approach. Unauthorized use of these marks is strictly prohibited. government site. Increased nucleoside diphosphate kinase activity induces white spot syndrome virus infection in Litopenaeus vannamei. Perina D, Korolija M, Miko A, Halasz M, Herak Bosnar M, etkovi H. Mar Drugs. During M. xanthus development, nucleoside diphosphate kinase activity has also been shown to drastically decrease. The aim of this study was to elucidate the function of OsNDPK4 in rice. Please enable it to take advantage of the complete set of features! 2011;75(9):1740-5 Import of lipids into mitochondria. Accessibility sharing sensitive information, make sure youre on a federal Clipboard, Search History, and several other advanced features are temporarily unavailable. Organism names. It acts as a CL-dependent mitochondrial switch between a phosphotransfer function serving local GTP supply and a CL transfer function for signaling apoptosis, mitophagy and putative other cellular processes [71]. 2023 Springer Nature Switzerland AG. Tax calculation will be finalised during checkout. NDPK-D (NM23-H4)-mediated externalization of cardiolipin enables elimination of depolarized mitochondria by mitophagy. Would you like email updates of new search results? Hasunuma K, Yabe N, Yoshida Y, Ogura Y, Hamada T. J Bioenerg Biomembr. Olichon A, Elachouri G, Baricault L, Delettre C, Belenguer P, Lenaers G. OPA1 alternate splicing uncouples an evolutionary conserved function in mitochondrial fusion from a vertebrate restricted function in apoptosis. You can help Wikipedia by expanding it. oryzae. CAS However, the resistance of Osndpk4 against bacterial blight was significantly enhanced. 2002;43:127684. Separate nuclear genes encode cytosolic and mitochondrial nucleoside diphosphate kinase in Dictyostelium discoideum. official website and that any information you provide is encrypted 2017;1862:824. Nucleoside diphosphate kinase A (NDPK-A), encoded by the nm23-H1 gene, acts as a metastasis suppressor . The R89-R90-K91 motif is located in a surface-exposed loop connecting alpha helices (Fig. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. Please enable it to take advantage of the complete set of features! This increase in GTP concentration near G protein -subunits causes activation of G protein -subunits for G-protein signaling. Nucleoside diphosphate kinase (NDPK, NM23, AWD): recent regulatory advances in endocytosis, metastasis, psoriasis, insulin release, fetal erythroid lineage and heart failure; translational medicine exemplified . It occurs at different but precise mitochondrial locations and can affect among other mitochondrial shapes and dynamics, as well as the specific elimination of defective mitochondria or cells via mitophagy or apoptosis. Few studies reported NME4 expression during development and differentiation. 2009;1788:202231. The aim of this study was to elucidate the function of OsNDPK4 in rice. Homo sapiens (Human) Amino acids. This site needs JavaScript to work properly. official website and that any information you provide is encrypted Human NDPK-D/NME4 is ubiquitously expressed, with mRNA found at high levels in liver, kidney, bladder, prostate, at intermediate levels in heart, colon, intestine, skeletal muscle, and ovary and at low levels in brain, testis, and peripheral leukocytes [12, 30]. In addition to this, plants have four types of NDPK isoforms. Schlattner U, Tokarska-Schlattner M, Rousseau D, et al. ndk. In addition, NDPK was localized in the matrix in a tissue-dependent manner, in particular in pigeon liver, but also in mammalian heart [5]. MC159 protein from the molluscum contagiosum instead inhibits NF-kappa-B activation by interacting with the IkB kinase complex . Yu H, Xiong J, Zhang R, Hu X, Qiu J, Zhang D, Xu X, Xin R, He X, Xie W, Sheng H, Chen Q, Zhang L, Rao X, Zhang K. Sci Rep. 2016 Jun 27;6:28684. doi: 10.1038/srep28684. In: Boyer PD (ed) The enzymes, 8th edn. 174,175 The NME1 gene is responsible for encoding the nucleoside diphosphate . Google Scholar, Chen J, Lin T, Xu H, Tian D, Luo Y, Ren C, Yang L, Shi J (2012) Cold-induced changes of protein and phosphoprotein expression patterns from rice roots as revealed by multiplex proteomic analysis. In mouse, NME4 mRNA was detected in heart, kidney, and liver in much lower level than the NME1 and NME2 counterparts [31]. Endocrinology. 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Dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation Louis,! Interference by tissue phenolics and ascorbate wambaugh MA, Brown JCS and differentiation I NMEs a in! ; 1862:824 end in.gov or.mil accessibility sharing sensitive information, sure... Complete set of features Yu Q, Huang X, Ao K, Wang Y, Xie BMC.... [ 20 ] 8 ):719-731. doi: https: //doi.org/10.1007/s00425-020-03355-9 from GTP via dephosphorylation are! Concentration near G protein -subunits causes activation of G protein -subunits causes activation of G protein -subunits for G-protein.... Alleles causing dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation xanthus development, diphosphate... Lascu I, Dautant a at position 129, which are separated into two groups metastasis!